Download Acute Myelogenous Leukemia: Genetics, Biology and Therapy by Zeev Estrov (auth.), Lalitha Nagarajan (eds.) PDF

By Zeev Estrov (auth.), Lalitha Nagarajan (eds.)

ISBN-10: 0387692576

ISBN-13: 9780387692579

Acute myelogenous leukemia (AML), is the commonest type of leukemia in adults. AML is a perilous type of malignancy, the diagnosis for which has no longer enhanced within the final twenty years. extra importantly, it's a malignancy that's visible in older adults, consequently the variety of situations is probably going to upward push because the inhabitants a long time.

Over the previous 15 years, genetic mechanisms underlying AML have all started to spread. extra learn during this region has helped determine key parts and features. for this reason, certain treatment of AML is receiving a lot awareness. it's the desire of researchers that as with continual myelogenous leukemia (CML), and the drug, Gleevec, a designated remedy for AML can be discovered.

"The potent therapy of acute myelogenous leukemia continues to be a superb problem. this article studies our realizing of the molecular and biologic foundation of the ailment. top investigators deal with advances in prognostication and healing innovations that experience major promise."

Steven T. Rosen, M.D.
Series Editor

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Additional info for Acute Myelogenous Leukemia: Genetics, Biology and Therapy

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Fusion proteins of the retinoic acid receptoralpha recruit histone deacetylase in promyelocytic leukaemia. Nature. 1998;391(6669): 815–818. 62. Guo SX, Taki T, Ohnishi H, et al. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia. Leuk Res. 2000;24(1):39–46. 63. Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci USA. 2003;100(8):4389–4394.

Genes Dev. 2001;15 (18):2343–2360. 174. Ziemin-van der Poel S, McCabe NR, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA. 1991;88(23):10735–10739. Chromosomal Translocations in AML: Detection and Prognostic Significance Nallasivam Palanisamy Introduction Clonal chromosome abnormalities are hallmarks of various cancer types. Non-random chromosome translocations have been identified in hematological malignancies over five decades due to their ability to yield informative metaphases.

29. Christman JK. 5-Azacytidine and 5-aza-20 -deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002;21 (35):5483–5495. 30. Cihak A, Vesely J. Prolongation of the lag period preceding the enhancement of thymidine and thymidylate kinase activity in regenerating rat liver by 5-azacytidine. Biochem Pharmacol. 1972;21(24):3257–3265. 31. Cihak A, Vesely J, Skoda J. Azapyrimidine nucleosides: metabolism and inhibitory mechanisms. Adv Enzyme Regul.

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Acute Myelogenous Leukemia: Genetics, Biology and Therapy by Zeev Estrov (auth.), Lalitha Nagarajan (eds.)

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