Download Acute Myelogenous Leukemia: Genetics, Biology and Therapy by Zeev Estrov (auth.), Lalitha Nagarajan (eds.) PDF

By Zeev Estrov (auth.), Lalitha Nagarajan (eds.)

ISBN-10: 0387692576

ISBN-13: 9780387692579

Acute myelogenous leukemia (AML), is the commonest type of leukemia in adults. AML is a perilous type of malignancy, the diagnosis for which has no longer enhanced within the final twenty years. extra importantly, it's a malignancy that's visible in older adults, consequently the variety of situations is probably going to upward push because the inhabitants a long time.

Over the previous 15 years, genetic mechanisms underlying AML have all started to spread. extra learn during this region has helped determine key parts and features. for this reason, certain treatment of AML is receiving a lot awareness. it's the desire of researchers that as with continual myelogenous leukemia (CML), and the drug, Gleevec, a designated remedy for AML can be discovered.

"The potent therapy of acute myelogenous leukemia continues to be a superb problem. this article studies our realizing of the molecular and biologic foundation of the ailment. top investigators deal with advances in prognostication and healing innovations that experience major promise."

Steven T. Rosen, M.D.
Series Editor

Show description

Read Online or Download Acute Myelogenous Leukemia: Genetics, Biology and Therapy PDF

Best biophysics books

Das Recht der Biomedizin: Textsammlung mit Einfuhrung

Die Textsammlung bietet eine Zusammenstellung aller wichtigen Rechtstexte v? lkerrechtlicher, gemeinschaftsrechtlicher und nationaler Natur aus dem Bereich der humanen Biomedizin. Sie erm? glicht hierdurch Wissenschaftlern, Praktikern, aber auch sonst an biomedizinisch und bioethischen Fragen Interessierten einen schnellen und handlichen Zugriff auf bislang nur verstreut publizierte Rechtsquellen.

Springer Handbook of Medical Technology

This concise, user-oriented and up to date table reference deals a huge creation to the attention-grabbing international of scientific know-how, totally contemplating today’s development and extra improvement in all suitable fields. The Springer instruction manual of scientific expertise is a systemized and well-structured guide which distinguishes itself via simplification and condensation of complicated proof.

Additional info for Acute Myelogenous Leukemia: Genetics, Biology and Therapy

Example text

Fusion proteins of the retinoic acid receptoralpha recruit histone deacetylase in promyelocytic leukaemia. Nature. 1998;391(6669): 815–818. 62. Guo SX, Taki T, Ohnishi H, et al. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia. Leuk Res. 2000;24(1):39–46. 63. Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci USA. 2003;100(8):4389–4394.

Genes Dev. 2001;15 (18):2343–2360. 174. Ziemin-van der Poel S, McCabe NR, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA. 1991;88(23):10735–10739. Chromosomal Translocations in AML: Detection and Prognostic Significance Nallasivam Palanisamy Introduction Clonal chromosome abnormalities are hallmarks of various cancer types. Non-random chromosome translocations have been identified in hematological malignancies over five decades due to their ability to yield informative metaphases.

29. Christman JK. 5-Azacytidine and 5-aza-20 -deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002;21 (35):5483–5495. 30. Cihak A, Vesely J. Prolongation of the lag period preceding the enhancement of thymidine and thymidylate kinase activity in regenerating rat liver by 5-azacytidine. Biochem Pharmacol. 1972;21(24):3257–3265. 31. Cihak A, Vesely J, Skoda J. Azapyrimidine nucleosides: metabolism and inhibitory mechanisms. Adv Enzyme Regul.

Download PDF sample

Acute Myelogenous Leukemia: Genetics, Biology and Therapy by Zeev Estrov (auth.), Lalitha Nagarajan (eds.)


by Charles
4.3

Rated 4.45 of 5 – based on 35 votes